Showing posts with label immune. Show all posts
Showing posts with label immune. Show all posts

In the modern world, no branch of the human family tree is known to be free of cancer, though rumors to the contrary keep popping up. In 1977 for example, the United Nations Educational, Scientific and Cultural Organization reported that the people of Pakistan's remote Hunza Valley showed no signs of the disease. The UN report was proved wrong; the Hunzas have insignificantly fewer cases of cancer than other populations of similar size, environment and occupation. Farmers in the uplands of Soviet Georgia - near the black sea - have long been an even richer source of health myth. They were once said to be not only cancer-free, but even immune to the aging process; tales abounded of people still active at the age of 125. But the accounts of fantastic longevity turned out to be based on provincial chauvinism and bad record-keeping. And the Soviet government, after an intensive study of the Georgians, reported in 1980 that they suffer as much breast, lung and cervical cancer as other Soviet peoples; in fact, only the incidence of stomach and esophageal cancer proved substantially lower than the average.

The facts about the Soviet Georgians illustrate an important truth about cancer. Although the affliction is universal, there are strange variations in its incidence, as a whole and by type. World Health Organization statistics showed that in 1974 and 1975 Scotland had a higher cancer death rate than any other country in the world - more than five and a half times higher than that of Thailand, the country with the fewest cases. Variations among types of cancer were even wider. Japan and Norway had much the same total cancer death rates, but the Japanese suffered three times more stomach cancer than the Norwegians; on the other hand, the death rate from breast cancer among Norwegian women was nearly four times higher than among the women of Japan.

Scientists can explain some of the variations in cancer incidence, including the appalling rate of stomach cancer in Japan. They are virtually certain that the Japanese diet, high in smoked and salted foods and in known carcinogen called bracken fern, is a major cause of that cancer. Elsewhere, specific cancers have been attributed to specific foods and other agents. But anomalies and mysteries remain. No one yet knows, for example why the cancer death rate is highest in Scotland. And no one knows why the breast cancer death rate is higher in Norway than in Japan, though some scientists have suggested that differences in childbearing or breast feeding customs may be the key.

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Cancer had been such a dark and fearful mystery because it takes so many forms. It can strike any organ, any tissue, anywhere in the body. Despite this diversity, all cancers share certain characteristic. They are all diseases of individual cells, the basic building blocks of plants and animals. No multicelled organism is immune to these diseases. A growth called crown gall, which appears on a number of plants, including daisies and tomatoes, exhibits certain characteristic of cancer. Insects get cancer; the fruit fly, a favourite creature of experimenters because it reproduces so rapidly - more than 35 generations per year - suffers from both brain tumors and blood cancers. Fish that swim through harbors polluted by tars and oil that cause cancer in human being develop cancers similar to human cancer. Dogs, cats, cows and horses get cancers of various types. Some wild animals such as cheetahs and certain asiatic bears, were once thought to be immune. They are not. Protected in a laboratory or a zoo from disease and their natural enemies, so that they consistently reach an age old for their species, they too develop the disease.

In all of these living thing, a cancer starts when something goes awry inside a cell, the smallest unit of living tissue. An error is somehow introduced into the genetic code, the complex pattern of molecules that normally ensures the reproduction of a new cell perfectly fitted to its function in the body. The genetic error may be caused by a chemical; by radiation therapy; or by the tiny agent of disease called virus. In addition, many genetic disruptions are simply random slippages of the cell's machinery, with no discernible cause. The result is the same : a new born freak cell called a mutant.
Few mutant cells survive long enough to do any damage. Some are so deformed or deficient that they wither and die; others are destroyed by the body's natural defenses. In a cancer victim - however - at least one such cell hangs on to life and eludes the body's defender. The cell divided into two, the two into four. Eventually, a billion or more may form a tumor, a swollen lump perceptible to the touch.

Rarely do swellings indicate the growth of new tissue and even more rarely are they dangerous. The hard knot that follows a bump on the head is simply an accumulation of fluid beneath the skin; other swellings are caused by pus at the site of an infection. Even a tumor consisting of mutant cells is seldom cancerous; most tumorous lumps are classified as benign and generally can be ignored. Only malignant or cancerous, tumors inevitably pose a thread to life.

Continue to "How Malignancy Begins (part 2)"
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